Claude 在 Anthropic 的 Claude Science 设置中以智能体形式独立完成蛋白质设计流程:选择毒素攻击位点、驱动 12 个蛋白质设计程序、自设评分标准,从 318,484 个生成分子中选出 180 个用于物理合成,211 个测试设计中 17 个在 Adaptyv Bio 和 Twist Bioscience 确认可结合蝎子毒素。
原文整理了 Claude 自主完成蛋白质设计的关键数字和流程细节,读者可以了解智能体在科学实验中的实际分工边界。
Claude did the protein scientist’s job and came back with 17 molecules that grip scorpion neurotoxins.
Claude, running as an agent inside Anthropic’s Claude Science setup, ran the whole protein-design campaign itself:
it picked which patch of each scorpion toxin to attack, drove 12 protein-design programs, set its own scoring cutoffs, and chose 180 molecules out of the 318,484 it generated for physical synthesis, and 17 of the 211 designs tested bound their toxin at Adaptyv Bio and Twist Bioscience.
Citrini Research, a finance firm with no lab and no protein expertise, asked for this work, and Claude designed proteins that two labs confirmed latch onto scorpion venom toxins.
Scorpion stings kill more than 3,250 people a year, so the prize is real, if this method works. However, Anthropic is not calling this an antivenom, because the test that would justify the word has not been run yet.
New on our Science Blog: designing protein binders against scorpion neurotoxins. Scorpions sting about 1.2m people every year, and antivenoms are often costly or in short supply. Claude has made an early step toward finding new treatments. https://www.anthropic.com/research/claude-scorpion-toxin-binder-design在 X 查看被引用的帖子
来源:Rohan Paul · x.com