X：小北

Many drugs work by binding to a specific target in the body and blocking or changing what it does. An important first step in the drug development process is designing a molecule that can bind tightly to its target. Traditionally, that's meant weeks or months of expert work per target, sifting through a large number of candidates to identify the few that work. We wanted to test if Claude could successfully design novel protein binders from scratch (also called de novo design). With a protein design prompt written by a human expert, Claude autonomously designed protein binders against 14 out of 15 targets. We then worked with Adaptyv Bio and Twist Bioscience, who independently built and tested the proteins Claude designed.

Fable 5 is state-of-the-art on nearly all tested benchmarks, with exceptional performance in software engineering, knowledge work, scientific research, and vision. The longer and more complex the task, the larger Fable 5’s lead over our other models.

Anthropic's Opus 4.7 and 4.8 models are experiencing degraded performance, which is causing a higher rate of failures for users selecting these models in Notion AI. To mitigate impact, all Anthropic models have been disabled in the model picker and requests have been rerouted to alternative providers. Most users should now be able to continue using Notion AI with minimal disruption, though Anthropic-specific features remain unavailable. Please refer to notion-status.com/ for the details.

x.com/i/article/206313956911…

“My company did layoffs a few weeks ago. The main metric for productivity is AI usage (% of PRs with AI assistance) and PR count per week. People are burnt out after layoffs, but they don’t want to be next so they are doing what’s requested: use AI, inflate PR count….”

Obsidian 加上 Codex，再配合合适的 API、MCP 和 Skills，基本上能替代目前 90% 以上的 AI Agent 产品。 这是我将笔记从 Notion 迁移到 Obsidian 一个月之后的感受。

懒猫摄像头开始预售啦！ 继懒猫微服，懒猫 AI 算力舱后，第三款懒猫智能硬件发布啦！ 星际太空人，科幻外观设计，从零开模打磨了一年半，头围和蔚来汽车的 Nomi 一样大，意味着买了摄像头后，所有 Nomi 的头饰都可以随意搭配 后期会让懒猫 AI 摄像头结合懒猫 AI 算力舱，让用户自定义 AI 大模型，实现 100% 隐私的家庭 AI 摄像头 最重要的一点是，懒猫 AI 摄像头是 NAS 界第一款智能摄像头，买回家扫码就可以用。以前那种购买第三方摄像头，破解 Token 各种折腾的时代结束彻底了！ 正式售卖价格 399 元，预售期间购买 360 元，评论区打 1，先到先得 想要免费获得这款科幻摄像头的推友，只需关注我，写任意评论并转发这个推特，下周三抽奖免费送 10 台懒猫 AI 摄像头，千万不要错过抽奖机会，0 门槛参与！！！

OpenAI 的野心和獠牙展现得比想象中更快。 CodeX 在其规划中已不再是程序员专属，而是走向更通用的 Agent。 为了让大家认识到这一点，以及具体帮哪些人做哪些事，OpenAI 主动晒出了数据分析、创意生产、销售、产品设计、股票投资和投行等插件。 未来适合更多工种的插件也会陆续上线。 Agent 帮更多人提效的时代，加速了。

We just released the Codex Python SDK 🔥 You can now embed Codex directly into your Python apps and workflows! > Start threads > Run turns > Stream progress > Resume sessions > Pass images > Control sandbox access All whilst reusing your existing Codex auth. pip install openai-codex Go build with it!!

We’re updating our ChatGPT Pro and Plus subscriptions to better support the growing use of Codex. We’re introducing a new $100/month Pro tier. This new tier offers 5x more Codex usage than Plus and is best for longer, high-effort Codex sessions. In ChatGPT, this new Pro tier still offers access to all Pro features, including the exclusive Pro model and unlimited access to Instant and Thinking models. To celebrate the launch, we’re increasing Codex usage for a limited time through May 31st so that Pro $100 subscribers get up to 10x usage of ChatGPT Plus on Codex to build your most ambitious ideas.

Five million users would agree. Resetting the limits tomorrow morning to celebrate. Time to go /fast

果然，竞争之下用户才能受益。 Claude 被封的陈年旧号可以申诉了。 Claude 他急了。

New in Claude Code (research preview): dynamic workflows. Claude writes an orchestration script on the fly, then spins up a large fleet of coordinated subagents in parallel to take on your most complex tasks. Use the word "workflow" in a prompt to get started.

You can add org-specific rules in a claude-security-guidance.md file. Drop it in your repo or distribute via MDM. The plugin enforces your policies alongside the built-in checks. Docs: code.claude.com/docs/en/secu…

刚群里有同学说agent这件事情已经结束了 我基本同意 感觉垂类Agent真没什么能做的了🥶🥶🥶🥶

他妈了个逼的，这到底画得是谁啊？！？！？！？！？

>started treating my Openclaw/Hermes like patients. >the bugs that kept coming back all had real medical names. take the one everyone calls "AI hallucination." medically it's confabulation. >now i scan for the organ that failed. gbrain handles memory. OpenClaw approvals handle actions. trajectory bundles handle self-check. >a healthier agent isn't a smarter brain. it's a more complete body. >a few weeks in, you stop blaming "the model." you find the broken organ and patch it. Video

各位好，这真的是我最后一个关于Anthropic的故事了，本视频由seedance2制作完成。感谢你一直以来对我的关注。结尾有彩蛋。 Video

拉勾网居然倒闭了 已申请破产

Some of you noticed limits drained faster in Codex, we root caused it to an optimization that we rolled back that had an impact on cache hit rates when compacting across long running sessions. We fixed this and have now reset usage limits for all accounts. Enjoy the weekend.

之前被封的Claude账号，居然可以登录了，登录之后会有申述引导。 这是察觉到Codex超车，搞了个用户召回策略？